Unconjugated hyperbilirubinemia:
● Haemolysis: ABO incompatibility, drugs, infection, G6PD deficiency.
● Bilirubin overproduction: Ineffective erythropoiesis, large hematoma
● Enzyme defects: Gilbert syndrome, Crigler-Najjar syndrome
● Hypothyroidism
● Specific conditions in neonates: Physiologic jaundice, breast milk jaundice
Conjugated hyperbilirubinemia:
● Neonatal cholestasis
● Infections
● CLD
● Liver tumour
● Malignancy
● Enzyme defects: Dubin-Johnson syndrome, Rotor syndrome
● Biliary: Choledochal cyst, choledocolithiasis, sclerosing cholangitis
● Drug toxicity, TPN, veno-occlusive disease
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